From: Ralf Hänel / Ralfone [rhaenel1@gmx.de]
Sent: 21 February 2011 12:17
To: rmathew@tagros.com
Cc: BURA Laszlo; zaimm@who.int; markus.mueller@acw.admin.ch
Subject: Re: CIPAC MT193

Attachments: MT 193_amended_2010.pdf

Dear Rajesh,

Due to the fact that I am not in the office today, I am using my private e-mail account.

Thank you very much for your comment. CIPAC appreciates always comments from colleagues who are using our methods.

During the CIPAC meeting in 2010 we have discussed the method MT 193 and the incorrect/misleading wording and formula. Please find attached to this e-mail a revised version of MT 193 that will be placed in short time on our website.

I hope that this addresses your question. However, do not hesitate to contact me if you have any further question.

Kind regards,
Ralf

PS: I have taken Markus Müller in Cc as he is the current chairman of the JMPS.

--------------------------------------------------
From: ""Ralf Hänel"" <ralf.haenel@bvl.bund.de>
Sent: Friday, February 18, 2011 7:10 AM
To: ""Dr. Ralf Hänel"" <rhaenel1@gmx.de>
Subject: WG: CIPAC MT193

>
>
> -----Ursprüngliche Nachricht-----
> Von: mathew [mailto:rmathew@tagros.com]
> Gesendet: Freitag, 18. Februar 2011 07:04
> An: ralf.haenel@bvl.bund.de
> Betreff: RE: CIPAC MT193
>
> Dear Dr. Ralf Haenel
>
>
>
> I hope you received the below mail
>
>
>
> Kind regards
>
> Rajesh Mathew
>
>
>
> From: mathew [mailto:rmathew@tagros.com]
> Sent: Saturday, February 12, 2011 11:11 AM
> To: 'ralf.haenel@bvl.bund.de'
> Cc: 'zaimm@who.int'; 'Laszlo.BURA@efsa.europa.eu'
> Subject: CIPAC MT193
>
>
>
> Dear Dr. Ralf Haenel
>
>
>
> This is to draw your kind attention to CIPAC MT 193 (FRIABILITY OF 
> TABLETS). WHO specification 333/WT (May 2008) for Deltamethrin WT 
> recommends CIPAC MT 193 for "Degree of attrition" and the 
> specification for attrition resistance is 95% minimum. If "attrition 
> resistance" means the percentage of unbroken tablet after the 
> friability test, please note that the formula to calculate the 
> Abrasion resistance given in MT 193 is wrong. This formula gives only 
> the percentage of friability only i.e. the percentage of broken 
> tablets. Therefore the actual formula should be R/E x 100. The current 
> formula is E-R/E x 100. Where E is the initial weight of the sample and R is the weight of the sample after the friability test.
>
>
>
>                       If MT 193 keeps the original formula the 
> specification for attrition should be "maximum 5%".   When we give 
> Deltamethrin WT sample to CRO to analyses the sample  for WHO 
> specified tests they use MT 193 for attrition resistance. Since the 
> formula is incorrect the sample do not pass WHO specification and we 
> get " out of specification" test reports. Kindly look into this 
> problem and hope to resolve it in the next JMPS meeting
>
>
>
> Best Regards
>
> Rajesh Mathew
>
>
>
>
>
> DGM-Regulatory affairs
>
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>
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>
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>
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>
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>
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>
>
>
>